hrp0097p1-204 | Adrenals and HPA Axis | ESPE2023
Vilmann Lea
, Siegfried Busch Alexander
, Lindhardt Ljubicic Marie
, N. Upners Emmie
, Bistrup Fischer Margit
, P. Hagen Casper
, Juul Anders
Background: Growth in infancy is considered primarily to be regulated by nutrition and insulin, whereas less is known about the influence of IGF-I, reproductive hormones and other factors of importance. Recently, paternally inherited genetic defects of DLK1 (Delta-like 1 homolog) were found in girls with central precocious puberty (CPP) with a metabolic phenotype. In addition, low maternal serum DLK1 concentrations were significantly lower in pregnant women wh...